Table of Contents
February 28, 2002
Volume 45, Issue 5
Pages 995-1150
Letters
Rhodacyanine Dyes as Antimalarials. 1. Preliminary Evaluation of Their Activity and Toxicity
Kiyosei Takasu, Hiroshi Inoue, Hye-Sook Kim, Makoto Suzuki, Tadao Shishido, Yusuke Wataya, and Masataka Ihara
pp 995–998Publication Date (Web): February 05, 2002 (Letter)
DOI: 10.1021/jm0155704
Hi-Res PDFIdentification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)
James F. Callahan, Joelle L. Burgess, James A. Fornwald, Laramie M. Gaster, John D. Harling, Frank P. Harrington, Jag Heer, Chet Kwon, Ruth Lehr, A. Mathur, Barbara A. Olson, Joseph Weinstock, and Nicholas J. Laping
pp 999–1001Publication Date (Web): January 30, 2002 (Letter)
DOI: 10.1021/jm010493y
Articles
Bis(1H-2-indolyl)methanones as a Novel Class of Inhibitors of the Platelet-Derived Growth Factor Receptor Kinase
Siavosh Mahboobi, Steffen Teller, Herwig Pongratz, Harald Hufsky, Andreas Sellmer, Alexander Botzki, Andrea Uecker, Thomas Beckers, Silke Baasner, Christoph Schächtele, Florian Überall, Matthias U. Kassack, Stefan Dove, and Frank-D. Böhmer
pp 1002–1018Publication Date (Web): January 30, 2002 (Article)
DOI: 10.1021/jm010988n
Solution Structure of a Putative HIV1 Immunogenic Peptide: Computer Simulation of the Principal CD4 Binding Domain of gp120
Dan Mihailescu, Jeremy C. Smith, and Jennifer Reed
pp 1019–1025Publication Date (Web): January 30, 2002 (Article)
DOI: 10.1021/jm0109715
Secondary Structure of the Third Extracellular Loop Responsible for Ligand Selectivity of a Mammalian Gonadotropin-Releasing Hormone Receptor
Renate Petry, David Craik, Gerald Haaima, Bernhard Fromme, Horst Klump, Wolfgang Kiefer, Dieter Palm, and Robert Millar
pp 1026–1034Publication Date (Web): February 05, 2002 (Article)
DOI: 10.1021/jm011036k
Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-c]quinazoline-2-carboxylates as Novel Excitatory Amino Acid Antagonists
Flavia Varano, Daniela Catarzi, Vittoria Colotta, Guido Filacchioni, Alessandro Galli, Chiara Costagli, and Vincenzo Carlà
pp 1035–1044Publication Date (Web): February 05, 2002 (Article)
DOI: 10.1021/jm010995b
Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 Integrins
Simon L. Goodman, Günter Hölzemann, Gábor A. G. Sulyok, and Horst Kessler
pp 1045–1051Publication Date (Web): January 31, 2002 (Article)
DOI: 10.1021/jm0102598
Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of New Diamine Containing Analogues
Stephen Hindley, Stephen A. Ward, Richard C. Storr, Natalie L. Searle, Patrick G. Bray, B. Kevin Park, Jill Davies, and Paul M. O'Neill
pp 1052–1063Publication Date (Web): February 01, 2002 (Article)
DOI: 10.1021/jm0109816
Synthesis and Nicotinic Binding Studies on Enantiopure Diazine Analogues of the Novel (2-Chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165
Holger Gohlke, Daniela Gündisch, Simone Schwarz, Gunther Seitz, Maria Cristina Tilotta, and Thomas Wegge
pp 1064–1072Publication Date (Web): February 05, 2002 (Article)
DOI: 10.1021/jm010936y
Synthesis and Biolocalization of Water-Soluble Sapphyrins
Vladimir Král, Julian Davis, Andrei Andrievsky, Jarmila Kralová, Alla Synytsya, Pavla Poucková, and Jonathan L. Sessler
pp 1073–1078Publication Date (Web): January 11, 2002 (Article)
DOI: 10.1021/jm0104320
Synthesis and Antitumor Activity of Several New Analogues of Penclomedine and Its Metabolites
Anita Tiwari, James M. Riordan, William R. Waud, and Robert F. Struck
pp 1079–1085Publication Date (Web): January 31, 2002 (Article)
DOI: 10.1021/jm010334e
6-Sulfonylchromenes as Highly Potent KATP-Channel Openers
Ekkehart Salamon, Raimund Mannhold, Horst Weber, Horst Lemoine, and Walter Frank
pp 1086–1097Publication Date (Web): February 01, 2002 (Article)
DOI: 10.1021/jm010999g
Feature Selection for Structure−Activity Correlation Using Binary Particle Swarms
Dimitris K. Agrafiotis and Walter Cedeño
pp 1098–1107Publication Date (Web): February 01, 2002 (Article)
DOI: 10.1021/jm0104668
Side-Chain Lactam-Bridge Conformational Constraints Differentiate the Activities of Salmon and Human Calcitonins and Reveal a New Design Concept for Potent Calcitonin Analogues
John W. Taylor, Qian K. Jin, Massimo Sbacchi, Lu Wang, Piero Belfiore, Martine Garnier, Athanasios Kazantzis, Aphrodite Kapurniotu, Paola F. Zaratin, and Mark A. Scheideler
pp 1108–1121Publication Date (Web): January 31, 2002 (Article)
DOI: 10.1021/jm010474o
Synthesis, Pharmacokinetics, Efficacy, and Rat Retinal Toxicity of a Novel Mitomycin C-Triamcinolone Acetonide Conjugate
Tamer A. Macky, Carsten Oelkers, Uwe Rix, Martin L. Heredia, Eva Künzel, Mark Wimberly, Baerbel Rohrer, Craig E. Crosson, and Jürgen Rohr
pp 1122–1127Publication Date (Web): February 05, 2002 (Article)
DOI: 10.1021/jm010511b
Development of a New Class of Nonimidazole Histamine H3 Receptor Ligands with Combined Inhibitory Histamine N-Methyltransferase Activity
Joachim Apelt, Xavier Ligneau, Heinz H. Pertz, Jean-Michel Arrang, C. Robin Ganellin, Jean-Charles Schwartz, Walter Schunack, and Holger Stark
pp 1128–1141Publication Date (Web): February 05, 2002 (Article)
DOI: 10.1021/jm0110845
Brief Articles
New Stereocontrolled Synthesis and Biological Evaluation of 5-(1‘-Hydroxyalkyl)-3-methylidenetetrahydro-2-furanones as Potential Cytotoxic Agents
Tomasz Janecki, Edyta Błaszczyk, Kazimierz Studzian, Marek Różalski, Urszula Krajewska, and Anna Janecka
pp 1142–1145Publication Date (Web): February 01, 2002 (Brief Article)
DOI: 10.1021/jm011019v
Synthesis and Biological Evaluation of a New Furo[2,3-h]quinolin-2(1H)-one
Adriana Chilin, Christine Marzano, Adriano Guiotto, Francarosa Baccichetti, Francesco Carlassare, and Franco Bordin
pp 1146–1149Publication Date (Web): January 30, 2002 (Brief Article)
DOI: 10.1021/jm010993r
Additions and Corrections
Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid: A Prodrug Approach for Targeting the Liver.
Gregory R. Bebernitz, Jeremy G. Dain, Rhonda O. Deems, Dario A. Otero, W. Ronald Simpson, and Robert J. Strohschein:
p 1150Publication Date (Web): January 23, 2002 (Addition/Correction)
DOI: 10.1021/jm010571h